Lasix or Furosemide is a diuretic. Violates the reabsorption of sodium ions, chlorine in a thick segment of the ascending part of the loop of Henle. Due to the increased excretion of sodium ions, a secondary (mediated osmotically bound water) enhanced water excretion and an increase in the secretion of potassium ions in the distal part of the renal tubule occurs. At the same time increases the excretion of calcium and magnesium ions.
It has secondary effects due to the release of intrarenal mediators and the redistribution of intrarenal blood flow. Against the background of a course of treatment, the effect does not weaken.
Furosemide, indications for use
- Edema in circulatory failure, liver and kidney diseases, difficulty in venous outflow, after burns and phlebothrombosis;
- ascites (against the background of malignant neoplasm, hepatic and cardiac origin);
- peripheral edema;
- pulmonary edema, incl. threatening, post-traumatic swelling of the brain, arterial hypertension;
- pregnancy toxicosis, generic eclampsia, premenstrual tension syndrome, preference uremia, hyperkalemia, forced diuresis (poisoning by chemical compounds, including barbiturates).
Side effects
Since the cardiovascular system: a pronounced decrease in blood pressure, collapse, tachycardia, arrhythmias, a tendency to thrombosis, a decrease in circulating blood volume.
From the side of the central nervous system: dizziness, headache, muscle weakness, gastrocnemius muscle cramps (tetany), paresthesia, apathy, weakness, weakness, lethargy, drowsiness, confusion.
From the senses: impaired vision and hearing, tinnitus.
On the part of the digestive system: anorexia, dry oral mucosa, thirst, nausea, vomiting, diarrhea, constipation, cholestatic jaundice, pancreatitis (exacerbation), hepatic encephalopathy.
Dosage
Tablets should be taken on an empty stomach, without chewing and washing down with a sufficient amount of liquid. When prescribing Furosemide, it is recommended to use its lowest dose, sufficient to achieve the desired effect. The maximum daily intake for adults is 1500 mg. The initial single dose in children is determined at the rate of 1-2 mg / kg of body weight / day with a possible increase in dose to a maximum of 6 mg / kg / day, provided the drug is taken no more than 6 hours. The duration of treatment is determined by the doctor individually, depending on from testimony.
Edematous syndrome in chronic heart failure: The initial dose is 20-80 mg / day. The required dose is selected depending on the diuretic response. It is recommended to divide the daily dose into 2-3 doses.