Human menopausal gonadotropin (HMG) in women causes an increase in the level of estrogen in the blood and stimulates the growth and maturation of the ovarian follicles, proliferation of the endometrium.
In men, the use of HMG increases the concentration of testosterone in the blood and stimulates spermatogenesis, acting on Sertoli of the seminiferous tubules. HMG is a natural drug used to stimulate ovulation in women who have certain difficulties with reproductive function. HMG contains LH (luteinizing hormone) and FSH (follicle-stimulating hormone) necessary to induce ovulation. HMG is isolated from the urine of postmenopausal women. After that, HMG is sterilized and then used to treat problems of the reproductive system.
HMG: indications for use
HMG is often used to stimulate ovulation in women suffering from:
- Ovulatory disorders such as PCOS (polycystic ovary syndrome)
- Endometriosis
- Problems with the pituitary gland if the pituitary gland cannot produce FSH or LH
The use of Clomid also does not give any results. It can also help men who have hormonal imbalances (causing the pituitary or hypothalamus), associated with low sperm levels, or poor sperm quality or sluggish mobility.
Efficiency of HMG
This is a very effective method of induction in most women. After using this drug, ovulation occurs in 75-85% of cases. The frequency of pregnancy, as a rule, is about 60%. Factors affecting the frequency of pregnancy, the fact that partners have sex, age and speed and motility of sperm partners. To talk with a specialist.
Side Effects of Human menopausal gonadotropin (HMG)
Many women on admission, pain on palpation of the abdomen, bloating, fluid retention and weight gain. Self-administration of injections can be quite difficult to provide. New, pure gonadotropin causes fewer side effects and may necessitate the use of smaller needles, rather than intramuscularly. The use of drugs that promote conception can be a great emotional stress for women, in addition to the precise controls required during each injection. In ovarian hyperstimulation syndrome (OHS), ovarian hyperstimulation syndrome develops. This disease is fatal, sudden severe abdominal pain, nausea, cancer, dehydration, head bolts and weight gain.
The ovaries quickly grow to sizes several times larger than the normal size (in connection with an excessively large number of eggs), and fluid leakage may occur in the abdominal cavity. If the patient has too many eggs, the doctor must notify her of multiple pregnancies due to sex or intense training. 40% of all pregnancies have a higher percentage of multiple pregnancies. The treatment method should cause many complications.
Human menopausal gonadotropin: Dosage and Administration
As a rule, it is taken in the form of intramuscular injections, usually two to three days after the onset of menstruation. HMG is administered daily for 7–12 days. The dosage may vary depending on the woman and the cycle, however, the typical dose is 75-600 IU per day, and this depends on how much egg takes time to mature. A doctor can demonstrate how to properly inject yourself. Therefore, it is necessary to conduct internal examinations, trans-vaginal ultrasound and blood tests. If the ultrasound shows that it is necessary to induce ovulation, it is necessary to inject HCG. Ovulation usually occurs 24 to 36 hours after the injection of HCG.
The patient then undergoes an intrauterine insemination procedure, scheduled one day or two after the injection. Most women undergo a maximum of 3-6 cycles of taking the drug. Increasing the duration of the drug does not guarantee successful treatment, so the doctor may increase the dose or suggest another type of treatment.