Doxee or doxycycline is a emisynthetic tetracycline, bacteriostatic broad-spectrum antibiotic. Penetrating into the cell, acts on intracellularly located pathogens. Suppresses the synthesis of proteins in the microbial cell, disrupts the connection of transport aminoacyl-RNA with the 30S subunit of the ribosomal membrane.
Indications
- infectious and inflammatory diseases caused by susceptible microorganisms: respiratory tract infections (pharyngitis, acute and chronic bronchitis, tracheitis, bronchopneumonia, lobar pneumonia, lung abscess, pleural empyema);
- infections of upper respiratory tract (otitis, tonsillitis, sinusitis, etc.);
- infections of the genitourinary system (cystitis, pyelonephritis, prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, endometritis, endocervicitis, acute orchiepididymitis; gonorrhea);
- infections of biliary tract and gastrointestinal tract (cholecystitis, cholangitis, gastroenterocolitis, bacterial dysentery, “travelers” diarrhea);
- infections of the skin and soft tissues (cellulitis, abscesses, furunculosis, panaritiums, infected burns, wounds, etc.);
- Infectious diseases of the eye, syphilis, frambesia, yersiniosis, legionellosis, rickettsiosis, chlamydia of various localization (including prostatitis and proctitis), Q fever, Rocky Mountains spotted fever, typhus (including sypha, tick, recurrent) , Lyme disease (I st. – erythema migrans), bacillary and amoebic dysentery, tularemia, cholera, actinomycosis, malaria; as part of combination therapy – leptospirosis, trachoma, psittacosis, ornithosis, granulocytic ehrlichiosis; whooping cough, brucellosis, osteomyelitis; sepsis, subacute septic endocarditis, peritonitis;
- prevention of postoperative purulent complications; malaria caused by Plasmodium falciparum during short-term travels (less than 4 months) in an area where chloroquine and / or pyrimethamine-sulfadoxine-resistant strains are common.
Side effects
- On the part of the nervous system: a benign increase in intracranial pressure (loss of appetite, vomiting, headache, swelling of the optic nerve head), toxic effects on the central nervous system (dizziness or instability),
- Metabolic disorders: anorexia.
- On the part of the hearing and vestibular apparatus: ringing in the ears.
- Visual organs: blurred vision, scotoma and diplopia as a result of increased intracranial pressure.
- On the part of the digestive system: nausea, constipation or diarrhea, abdominal pain, glossitis, dysphagia, esophagitis (including erosive), gastritis, ulceration of the stomach and duodenum 12, pseudomembranous colitis, enterocolitis (due to proliferation of resistant strains of staphylococcal ).
- Allergic reactions: maculopapular rash, pruritus, skin flushes, angioedea, mollusks, anaphylactoid reactions, drug-induced lupus erythematosus, erythematous rash, exfoliative dermatitis, urticaria, anaphylaxis, anaphylactic shock, anaphylaxis, anaphylaxis, anaphylaxis, urticaria, anaphylaxis, anaphylactic shock, anaphylaxis, rash, urticaria, anaphylaxis, anaphylactic shock, anaphylaxis, rash, exfoliative dermatitis, urticaria, anaphylaxis, anaphylactic shock, anaphylaxis.
- Cardiovascular system: pericarditis, lowering blood pressure, tachycardia, erythema multiforme.
Dosage
Inside, in adults and children over 12 years old with a body weight of more than 45 kg, the average daily dose is 200 mg on the first day (divided into 2 doses – 100 mg 2 times a day), then 100 mg / day.
- With chronic urinary system infections – 200 mg / day throughout the entire period of therapy.
- In the treatment of gonorrhea, prescribed according to one of the following schemes: acute uncomplicated urethritis – a course dose of 500 mg (1 dose – 300 mg, the next 2 – 100 mg each with an interval of 6 hours) or 100 mg / day until complete cure (in women) or 100 mg 2 times a day for 7 days (for men); with complicated forms of gonorrhea, the course dose is 800-900 mg, which is divided into 6-7 doses (300 mg – 1 dose, then with an interval of 6 hours for 5-6 subsequent).
- In the treatment of syphilis – 300 mg / day for at least 10 days.
- For uncomplicated infections of the urethra, cervix and rectum caused by Chlamydia trachomatis, 100 mg are prescribed 2 times a day for at least 7 days.
- Infections of the male genital organs – 100 mg 2 times a day for 4 weeks. Treatment of chloroquine-resistant malaria – 200 mg / day for 7 days (in combination with schizontocidal drugs – quinine); malaria prophylaxis -100 mg 1 time per day 1-2 days before the trip, then daily during the trip and for 4 weeks after returning;
- Diarrhea “travelers” (prevention) – 200 mg on the first day of the trip (for 1 reception or 100 mg 2 times a day), 100 mg 1 time a day during the entire stay in the region (no more than 3 weeks).
- Treatment of leptospirosis – 100 mg orally 2 times a day for 7 days; prevention of leptospirosis – 200 mg once a week during a stay in a disadvantaged area and 200 mg at the end of the trip.
- Prevention of infections after medical abortion – 100 mg 1 hour before abortion and 200 mg – 30 minutes after.
- With acne – 100 mg / day, the course – 6-12 weeks.