Generic Zovirax (Acyclovir) is active against Herpes simplex 1 and 2 types, Varicella zoster virus, Epstein-Barr virus and cytomegalovirus.
Thymidine kinase of virus-infected cells through a series of successive reactions actively converts acyclovir into mono-, di-, and acyclovir triphosphate. The latter interacts with viral DNA polymerase and is incorporated into DNA, which is synthesized for new viruses. Thus, “defective” viral DNA is formed, which leads to the suppression of the replication of new generations of viruses.
Indications for use
The drug is intended for local and systemic use in patients with such diseases:
- infectious diseases of the skin and mucous membranes caused by the herpes virus type I and II, including for the treatment of
- primary genital herpes and its recurrence;
- infectious diseases caused by varicella-zoster virus and herpes zoster;
- Herpes infection I and II type in newborns;
- the drug is also used for the prevention of infectious diseases caused by the herpes simplex virus in immunocompromised patients;
- for the prevention of cytomegalovirus infection during bone marrow transplantation operations.
When applying the cream may develop local side effects such as itching, burning, irritation of the skin at the site of application. In addition, patients had dry and flaky skin, development of contact dermatitis. Allergic reactions in the form of angioedema were rarely observed.
The drug is used topically. A small amount of cream is applied to the affected areas up to 5 times per day. The course of treatment is usually 4 days. If necessary, the duration of treatment can be extended to 10 days.